High Performance Liquid Chromatography (HPLC)

Mass spectrometers used for the analysis of macromolecules from biological sources, such as proteins, peptides, DNA or RNA oligomers, have experienced tremendous improvements in recent years. Mass spectrometry is fast becoming an indispensable field for analyzing biomolecules. Till the1970s, the only analytical techniques which provided similar information were electrophoretic, chromatographic or ultracentrifugation methods. The results were not absolute as they were based on characteristics other than the molecular weight. Thus the only possibility of knowing the exact molecular weight of a macromolecule remained its calculation based on its chemical structure.

  • High-pressure pump
  • Detector

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